antisocial personality disorder lying behavior of MRI

Title: antisocial personality disorder lying behavior of MRI
Author: Liu Jian
Degree-granting units: Central South University
Keywords: antisocial personality disorder;; lying;; functional magnetic resonance imaging;; gray matter
Abstract:
Objective: Using blood oxygenation level dependent functional magnetic resonance imaging and brain magnetic resonance imaging three-dimensional structure of excessive lying behavior antisocial personality disorders (antisocial personaility disorder, APD) in the lying brain activation patterns and associated with the nerve lying contact, and no excess of such people and lying behavior of APD between patients and normal brain function and the existence of significant differences in brain structure.
Methods: 17 patients meet DSM-IV diagnosis of excessive lying behavior of untreated male patients with APD, 18 patients without excessive lying behavior of untreated male patients with APD and 19 normal men, using the Minnesota Multiphasic Personality Inventory evaluation, three groups in age, gender, IQ and educational level of the match. Application of the three groups for 1.5T MRI scan and three-dimensional structure like in the real presentation, misrepresentation and lying in a functional task such as scanning. Use of behavioral data SPSS13.0 software analysis. fMRI data using SPM2 software analysis, comparing three groups in three conditions, differences in brain activation patterns. Analysis of three-dimensional structure as voxel-based morphology, compared three groups of differences in brain gray matter structures.
Results: successful completion of the psychological evaluation and magnetic resonance scanning, and into the statistics of the study including 17 cases of excessive lying behavior of APD patients, 18 patients without excessive lying behavior of APD patients and 19 normal controls. Three groups of study of brain structure and in the real presentation, misrepresentation and lying under the task of brain activation and brain structure of three groups to compare differences in results are as follows: 1 compared with the real mission statement, misrepresentation and lying tasks in each group were significantly longer reaction time (P <0.05). And misrepresent the true task of the correct response rate in each group were not significantly different (P> 0.05). (2) normal control group in a real mission statements, there is the inside back left frontal (BA10), left cingulate gyrus (BA31), bilateral temporal lobe (BA20, BA38, BA39), the right cerebellum activation. Misrepresentation in the task, there are bilateral precuneus (BA31, BA19), right temporal gyrus (BA21), bilateral superior temporal gyrus (BA21, BA22), left corner of the back (BA39), left after the central back (BA1 ), left anterior cingulate gyrus (BA32), right insula (BA13) and right cerebellar activation. Lying tasks, there is the left precuneus (BA19), right frontal lobe (BA6, BA8, BA9, BA46), bilateral temporal lobe (BA21, BA22, BA41, BA42, BA38, BA39), bilateral hippocampus, Right precentral gyrus (BA4, 6), bilateral cerebellar activation. Misrepresent the true mission statement comparing the task, increased activation of brain areas are left cerebellum. Mission statement misrepresentation real comparison task, no significant increase in activation of brain regions. Mission statement lies the real contrast, increased activation of frontal brain regions are (BA6, BA9, BA46), inferior parietal lobule (BA40), the right inferior temporal gyrus (BA20) and bilateral cerebellum. Mission statement lies the real task of comparison, the increase in brain activation are central gyrus (BA4). Lying misrepresentation tasks than bilateral inferior parietal lobule (BA40), the right middle frontal gyrus (BA6, BA9, BA46), left frontal medial back (BA8) and left cerebellum activation increased. Misrepresentation task contrast lies the task, no significant increase in activation of brain regions. 3. Antisocial personality disorder expressed in the real task of the control group activated the left frontal brain areas are (BA9, BA8), the left temporal gyrus (BA39), right-central gyrus (BA4) and right cerebellum. Mission statement in the wrong area of ​​the brain are activated under the left precuneus (BA7), left superior frontal gyrus (BA8) and right precentral gyrus (BA4). Lying task activated the right frontal brain areas are (BA6, BA8, BA9, BA45), cingulate gyrus (BA24, BA31), the right inferior parietal lobule (BA40), left hippocampus, left insula (BA13) and right central gyrus (BA6, BA43). In contrast to misrepresent the true mission statement task, the activation of additional brain areas are: the right cerebellum. Mission statement misrepresentation real comparison task, increased activation of brain areas are left after the central back (BA3, 40), left precentral gyrus (BA4), left hippocampus. Mission statement lies the real task contrast, increased activation of right frontal brain regions (BA6, BA8), the left frontal lobe (BA8, BA9, BA10, BA46), the right superior temporal gyrus (BA39), the right inferior parietal lobule (BA39) , the left inferior parietal lobule (BA40), left cingulate gyrus (BA32), bilateral cerebellum. Mission statement lies the real task of comparison, the increase in brain activation of left precentral gyrus (BA6). Lying misrepresentation task task contrast, activation of brain areas have increased bilateral parietal, bilateral cingulate gyrus (BA32), the inside of the right amount of back (BA8), the left cerebellum. Misrepresentation task contrast lies the task, no significant increase in activation of brain regions. 4. Lying group of antisocial personality disorder expressed in the real task of the brain regions activated in the inside back with left frontal (BA10), left superior temporal gyrus (BA38), left temporal gyrus (BA21), the right occipital lobe (BA19) and left beside the central lobular (BA6). Mission statement in the wrong area of ​​the brain are activated inside the back left frontal (BA10), the inside of the right amount of back (BA6), right-central gyrus (BA6), right anterior cingulate gyrus (BA32) and left after the central back (BA43) , bilateral temporal lobe (BA21, BA22, BA38) and the amygdala. Lying task activated brain areas have the right parietal lobe (BA7, 40), the left frontal lobe (BA8, 9,46) and left insula (BA13). In contrast to misrepresent the true mission statement task, the activation of additional brain areas are: the left inferior parietal lobule (BA40). Real mission statement misrepresentation under the task contrast, no significant increase in activation of brain regions. Mission statement lies the real task contrast, increased activation of frontal brain areas are (BA8, BA9, BA10, BA47), bilateral parietal lobe, right precentral gyrus (BA44), the right insula (BA13), bilateral cerebellum. Mission statement lies the real task contrast, no significant increase in activation of brain regions. Lying misrepresentation task task contrast, increased activation of frontal brain areas are (BA8, BA9, BA45, 46), the right inferior parietal lobule (BA40), thalamus and bilateral cerebellum. Misrepresentation task contrast lies the task, no significant increase in activation of brain regions. 5. Misrepresentation task, normal control group than in the APD group lying areas of the brain are activated to increase the left cingulate gyrus (BA31), right-central gyrus (BA4) and right temporal gyrus (BA37). APD group compared to normal group lying areas of the brain are activated to increase bilateral inferior parietal lobule (BA40), precuneus (BA7), left frontal lobe (BA8, 10,46) and left temporal lobe (BA20). Normal control group than in the control group, APD increased activation in brain areas have left precuneus (BA19) and left cerebellum. APD group than the control group increased brain activation of left superior temporal gyrus (BA22). APD APD lying group than the control group increased activation of brain areas are left precuneus (BA7), left frontal (BA6, 8), left inferior parietal lobule (BA40) and right cerebellum. APD APD lying group than the control group, no significant increase in activation of brain regions. Magnetic lifter 6 lying tasks, APD lying group compared to normal control group, increased activation of left frontal brain areas are (BA6, 46), right-back after the central (BA2, 40), left precuneus (BA7, 19), left temporal lobe (BA21, 22) and right cerebellum. Normal control group compared APD lying group, no significant increase in activation of brain regions. APD group compared to normal control group, normal control group compared APD control group, no significant increase in activation of brain regions. APD APD lying group compared the control group increased activation of brain areas are left precuneus (BA19), left temporal lobe (BA37, 39), the left frontal lobe (BA6, 46), left cingulate gyrus (BA24), the right occipital lobe and right cerebellum. APD APD lying group compared the control group no significant increase in activation of brain regions. 7 with the normal control group, APD control group patients have the right inferior parietal lobule (BA40), left superior frontal gyrus (BAll) and middle frontal gyrus (BA9), bilateral precuneus (BA7), left fusiform gyrus (BA37), left cingulate gyrus (BA24) and bilateral cerebellar gray matter density. Compared with normal group, APD group mainly left superior temporal gyrus (BA38) and left parahippocampal gyrus (BA30) of the density increase. With the normal control group, APD lying group bilateral fusiform gyrus (BA37, 19), bilateral temporal gyrus (BA21), left cerebellar gray matter density. Compared with the control group, APD, APD lying group left cerebellum and right temporal gyrus (BA39, 21) of gray matter density decrease.
Conclusion: 1. Lying and the real difference between the cognitive fMRI can detect differences in neural connections, a true expression of inhibition may be cheating the main component of the prefrontal neural circuits is to deceive the basic ingredients. 2. There are too many acts of antisocial personality disorder lying people, lying in the brain has its unique activation patterns, mainly for the precuneus, dorsolateral prefrontal, cingulate gyrus and increased activation of the cerebellum may be The behavior of too many lying neuropathological basis. 3. Without too much lying behavior of antisocial personality disorder lies in the implementation of the task compared with the normal brain activation patterns are basically the same. Shows two groups lying areas of the brain activation patterns when no differences in anti-social groups and the heterogeneity of the normal population lying under the brain areas activated for no apparent impact. Antisocial personality disorder is not in itself lead to http://www.999magnet.com/ activation of brain regions lying under the unusual task of reason. 4. Antisocial personality disorder may exist in brain anatomy and lying on the neural circuits related to abnormal behavior, including the dorsolateral prefrontal - cingulate gyrus - precuneus - temporal lobe - abnormal cerebellar circuit, which may be antisocial personality disorder neurological pathology.
Degree Year: 2010